Phosphatidylserine
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Phospholipid component of cell membranes, vital for brain cells
Moderate evidence for improving memory and attention in the elderly
Moderate evidence for reducing ADHD symptoms and cortisol levels
Excellent safety; naturally occurring in the brain
Relatively expensive: ~$25-40/month
Best for: Memory support, stress-related 'brain fog'
What it is
Phosphatidylserine (PS) is a 'structural' nutrient. It makes up a large part of the fatty membrane that surrounds every neuron. It is essential for cell-to-cell communication and for the clearance of old, damaged brain cells. Historically derived from cow brains, modern PS is safely made from soy or sunflower lecithin.
What the research says
PS is a building block for a sharp mind. Evidence. Multiple small RCTs have shown that PS supplementation (100mg 3x daily) improves memory, word recall, and mood in elderly participants with early-stage memory loss. Cortisol. It is also uniquely effective at lowering high cortisol levels after physical or mental stress, protecting the brain from 'stress-induced' shrinkage. [1][2][3][4]
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Phosphatidylserine on Amazon
Safety
Extremely safe. It is a natural part of the human diet (found in organ meats and fish). No significant side effects at standard doses.
Interactions
- Cholinergic Drugs: May theoretically potentiate drugs like Aricept used for Alzheimer's.
Dosing
Standard Dose: 100 mg taken 3 times daily (300mg total). Form: Ensure it is derived from sunflower or soy to avoid old-fashioned 'bovine' sources.
Cost
Moderate-to-high. $25-40 per month.
The bottom line
PS is 'brain food' in the literal sense. It's a foundational nutrient for maintaining the physical structure of your neurons as you age.
References
- Kato-Kataoka A, Sakai M, Ebina R, et al. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010;47(3):246-255.
- Jorissen BL, Brouns F, Van Boxtel MP, et al. The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci. 2001;4(2):121-134.
- Monteleone P, Beinat L, Tanzillo C, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990;52(3):243-248.
- Hellhammer J, Fries E, Buss C, et al. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004;7(2):119-126.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.