Chamomile
Content by: OpenSupplement Editorial Team | Medical review: pending | Last updated: April 13, 2026
TL;DR
Gentle herbal sedative containing the antioxidant apigenin
Moderate evidence for reducing anxiety and improving sleep quality
Mild mechanism: Apigenin binds to GABA receptors in the brain
Excellent safety profile; very low toxicity
Very cheap: ~$5-10/month
Best for: Mild insomnia, nighttime anxiety, digestive calming
What it is
Chamomile is one of the most ancient medicinal herbs known to mankind. While most people know it as a tea, concentrated extracts are used for therapeutic purposes. The primary active constituent for sleep is a flavonoid called apigenin.
Apigenin is unique because it binds to benzodiazepine receptors in the brain, but much more gently than pharmaceutical drugs. This provides a mild tranquilizing effect that helps quiet the mind before bed. Chamomile also has anti-inflammatory and antispasmodic properties, making it helpful if digestive upset is contributing to poor sleep.
What the research says
The evidence for chamomile is positive but generally shows a mild effect size. Clinical Trials. A 2011 RCT by Zick et al. found that while chamomile didn't significantly change sleep latency compared to placebo, it did improve daytime functioning in chronic insomniacs. Anxiety Link. A study in Phytomedicine (2016) showed that long-term chamomile pharmaceutical-grade extract significantly reduced symptoms of moderate-to-severe Generalized Anxiety Disorder (GAD), which is a major driver of sleep issues. Recommendation. It is best used as a 'lifestyle' supplement or as part of a calming nighttime stack rather than a heavy-duty sleep inducer. [1][2][3]
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Chamomile on Amazon
Safety
Extremely safe for most. People with allergies to the Asteraceae family (ragweed, daisies, marigolds) should be cautious as cross-reactivity can occur.
Interactions
- Warfarin/Blood Thinners: Contains small amounts of coumarin; may theoretically increase bleeding risk at very high doses.
- Sedatives: May have mild additive effects.
Dosing
For Sleep/Anxiety: 220-400 mg of standardized extract (1.2% apigenin) 2-3 times daily, or a concentrated dose before bed. Form: High-potency extract capsules are more effective than tea for clinical outcomes.
Cost
Very affordable. Monthly supply of capsules is typically $5-10.
The bottom line
Chamomile is the 'kindest' sleep supplement. It won't knock you out, but it can take the edge off a stressful day and promote a more restful state of mind.
References
- Zick SM, Wright BD, et al. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011;11:78.
- Adib-Hajbaghery M, Mousavi SN. The effects of chamomile extract on sleep quality among elderly people: a clinical trial. Complement Ther Med. 2017;35:109-114.
- Srivastava JK, Shankar E, Gupta S. Chamomile: a herbal medicine of the past with bright future. Mol Med Rep. 2010;3(6):895-901.
Sources for this page include published meta-analyses, systematic reviews, and NIH dietary supplement fact sheets. All claims reflect the evidence as of early 2026.
This is not medical advice. Consult your healthcare provider before starting any supplement, especially if you take medications.